0145 Associations Among Childhood Stress, Actigraphy-Measured Sleep Efficiency, and Fasting Glucose Concentrations in Young Adults

Abstract Introduction Psychosocial stress exposure during the first 18 years of life promotes adverse sleep and cardiometabolic health effects. The purpose study was to investigate relationships between childhood (CS), efficiency (SE), fasting glucose levels (FG) in young adulthood. Methods In 24 adults ages 35 (83% Female; mean±SD, age = 24±5 y), CS assessed using a retrospective assessment averaged across reference 5, 10, 15 old. FG concentrations were obtained from whole blood samples SE an actigraphy device (ActTrust2) worn on wrist for 7 days, yielding ≥6 days data. Zero-order correlations used among CS, SE, FG. Multiple linear regression analyses examine effect controlling sex. To explore preliminary indications mechanistic link FG, ANCOVA analysis used. Participants grouped as either low (CS-low) or high (CS-high), completed with sex only covariate covariates, outcome. Results associated (r=0.50, p=0.01) (r=-0.41, p=0.47), (r=-0.45, p=0.03). association (β=0.51, p=0.016) (β=-0.43, p=0.046) remained adjustment confirmed where higher CS-high than CS-low (92.4±4.8 vs. 83.6±5.4 mg/dL; p=0.008). Additional reduced difference CS-low, but this significant (91.6±5.0 84.5±5.5 p=0.044). Conclusion is linked elevated adults. Our data suggest that warrants further examination potential mechanism by which relates larger sample sizes will be necessary draw definitive conclusions. Support (if any) Research reported publication supported part NCATS NIH (UL1TR002537) Injury Prevention Center through CDC (R49 CE003095).